dihydropyridine derivatives as cell growth modulators in vitro

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ID: 185386
2017
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Abstract
The effects of eleven 1,4-dihydropyridine derivatives (DHPs) used alone or together with prooxidant anticancer drug doxorubicin were examined on two cancer (HOS, HeLa) and two nonmalignant cell lines (HMEC, L929). Their effects on the cell growth (3H-thymidine incorporation) were compared with their antiradical activities (DPPH assay), using well-known DHP antioxidant diludine as a reference. Thus, tested DHPs belong to three groups: (1) antioxidant diludine; (2) derivatives with pyridinium moieties at position 4 of the 1,4-DHP ring; (3) DHPs containing cationic methylene onium (pyridinium, trialkylammonium) moieties at positions 2 and 6 of the 1,4-DHP ring. Diludine and DHPs of group 3 exerted antiradical activities, unlike compounds of group 2. However, novel DHPs had cell type and concentration dependent effects on 3H-thymidine incorporation, while diludine did not. Hence, IB-32 (group 2) suppressed the growth of HOS and HeLa, enhancing growth of L929 cells, while K-2-11 (group 3) enhanced growth of every cell line tested, even in the presence of doxorubicin. Therefore, growth regulating and antiradical activity principles of novel DHPs should be further studied to find if DHPs of group 2 could selectively suppress cancer growth and if those of group 3 promote wound healing.
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bruvere2017oxidativedihydropyridine Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Imanta Bruvere;Egils Bisenieks;Janis Poikans;Janis Uldrikis;Aiva Plotniece;Karlis Pajuste;Martins Rucins;Brigita Vigante;Zenta Kalme;Marina Gosteva;Ilona Domracheva;Astrida Velena;Tea Vukovic;Lidija Milkovic;Gunars Duburs;Neven Zarkovic
Journal journal of aoac international
Year 2017
DOI
10.1155/2017/4069839
URL
http://dx.doi.org/10.1155/2017/4069839
Keywords
cytology

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