norovírus: uma visão geral norovirus: an overview
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ID: 185301
2011
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Abstract
Os norovírus (NoV) foram os primeiros agentes virais ligados à doença gastrointestinal, entretanto, eles foram, por muito tempo, considerados como causa secundária de gastroenterite, após os rotavírus. O desenvolvimento de técnicas moleculares voltadas ao diagnóstico dos NoV forneceu dados mais claros sobre o impacto epidemiológico desses vírus, os quais são, atualmente, reconhecidos não apenas como principal causa de surtos de gastroenterite não bacteriana, mas também como causa importante de gastroenterite esporádica em crianças e adultos. Esta revisão enfoca os conhecimentos necessários para compreender a sua morfologia, genética, transmissão, patogênese e controle. Uma vez que não há vacina disponível, a prevenção da infecção por NoV depende principalmente de medidas de higiene da comunidade e pessoais.
Although noroviruses (NoVs) were the first viral agents linked to gastrointestinal disease, for a long time they have been considered secondary cause of gastroenteritis, second to rotaviruses as etiologic agents. The development of molecular techniques in diagnosing NoV provided a clearer insight into the epidemiological impact of these viruses, which are currently recognized not only as the leading cause of non-bacterial gastroenteritis outbreaks, but also as a major cause of sporadic gastroenteritis in both children and adults. This review focuses on the required knowledge to understand their morphology, genetics, transmission, pathogenesis, and control. Since no vaccine is available, prevention of NoV infection relies mainly on strict community and personal hygiene measures.
Although noroviruses (NoVs) were the first viral agents linked to gastrointestinal disease, for a long time they have been considered secondary cause of gastroenteritis, second to rotaviruses as etiologic agents. The development of molecular techniques in diagnosing NoV provided a clearer insight into the epidemiological impact of these viruses, which are currently recognized not only as the leading cause of non-bacterial gastroenteritis outbreaks, but also as a major cause of sporadic gastroenteritis in both children and adults. This review focuses on the required knowledge to understand their morphology, genetics, transmission, pathogenesis, and control. Since no vaccine is available, prevention of NoV infection relies mainly on strict community and personal hygiene measures.
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| Authors | ;Simone Guadagnucci Morillo;Maria do Carmo Sampaio Tavares Timenetsky |
| Journal | acta crystallographica section e |
| Year | 2011 |
| DOI |
10.1590/S0104-42302011000400023
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