physeal bystander effects in rhabdomyosarcoma radiotherapy: experiments in a new xenograft model

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ID: 185183
2011
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Abstract
Radiotherapy used in the treatment of pediatric musculoskeletal sarcomas may result in crippling defects of skeletal growth. Several radioprotective strategies have shown potential for preserving function of the irradiated epiphysis but have not been evaluated in a tumor-bearing animal model. We developed two bioluminescent human rhabdomyosarcoma cell lines that were used to establish xenograft tumors in skeletally immature mice. Bioluminescence imaging and radiography allowed serial evaluation of tumor growth and tibial elongation following localized radiotherapy. High-dose (10 Gy) radiotherapy significantly reduced tumor growth velocity and prolonged the median survival of tumor-bearing mice but also resulted in a significant 3.3% shortening of the irradiated limb. Exposure to a lower, 2 Gy dose resulted in 4.1% decrease in limb length but did not extend survival. This new model provides a clinically relevant means to test the efficacy and safety of novel radioprotectant and radiorecovery strategies for use in this context.
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horton2011sarcomaphyseal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Jason A. Horton;Judith A. Strauss;Matthew J. Allen;Timothy A. Damron
Journal the journal of physiology
Year 2011
DOI
10.1155/2011/815190
URL
http://dx.doi.org/10.1155/2011/815190
Keywords
neoplasms Oncology including cancer and carcinogens tumors

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