effects of psa removal from ncam on the critical period plasticity triggered by the antidepressant fluoxetine in the visual cortex

Efek penghilangan PSA dari NCAM terhadap plastisitas periode kritis yang dipicu oleh antidepresan fluoksetin pada korteks visual

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ID: 185107
2016
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Abstract
Neuronal plasticity peaks during critical periods of postnatal development and is reduced towards adulthood. Recent data suggests that windows of juvenile-like plasticity can be triggered in the adult brain by antidepressant drugs such as Fluoxetine. Although the exact mechanisms of how Fluoxetine promotes such plasticity remains unknown, several studies indicate that inhibitory circuits play an important role. The polysialylated form of the neural cell adhesion molecules (PSA-NCAM) has been suggested to mediate the effects of Fluoxetine and it is expressed in the adult brain by mature interneurons. Moreover, the enzymatic removal of PSA by neuroaminidase-N not only affects the structure of interneurons but also has been shown to play a role in the onset of critical periods during development. We have here used ocular dominance plasticity in the mouse visual cortex as a model to investigate whether removal of PSA might influence the Fluoxetine-induced plasticity. We demonstrate that PSA removal in the adult visual cortex alters neither the baseline ocular dominance, nor the fluoxetine-induced shift in the ocular dominance. We also show that both chronic Fluoxetine treatment and PSA removal independently increase the basal FosB expression in parvalbumin interneurons in the primary visual cortex. Therefore, our data suggest that although PSA-NCAM regulates inhibitory circuitry, it is not required for the reactivation of juvenile-like plasticity triggered by Fluoxetine.
Plastisitas neuronal mencapai puncaknya selama periode kritis perkembangan pascalahir dan berkurang menjelang usia dewasa. Data terkini menunjukkan bahwa jendela plastisitas serupa-juvenil dapat dipicu pada otak dewasa oleh obat antidepresan seperti Fluoxetine. Meskipun mekanisme pasti mengenai bagaimana Fluoxetine mendorong plastisitas tersebut masih belum diketahui, beberapa penelitian menunjukkan bahwa sirkuit inhibitorik memainkan peran penting. Bentuk terpolisialasi dari molekul adhesi sel saraf (PSA-NCAM) diduga memediasi efek Fluoxetine dan diekspresikan pada otak dewasa oleh interneuron matang. Selain itu, penghilangan enzimatik PSA oleh neuroaminidase-N tidak hanya memengaruhi struktur interneuron, tetapi juga telah terbukti berperan dalam awitan periode kritis selama perkembangan. Di sini, kami menggunakan plastisitas dominansi okular pada korteks visual mencit sebagai model untuk menyelidiki apakah penghilangan PSA dapat memengaruhi plastisitas yang diinduksi oleh Fluoxetine. Kami menunjukkan bahwa penghilangan PSA pada korteks visual dewasa tidak mengubah dominansi okular dasar maupun pergeseran dominansi okular yang diinduksi oleh fluoxetine. Kami juga menunjukkan bahwa baik perlakuan Fluoxetine kronis maupun penghilangan PSA secara independen meningkatkan ekspresi basal FosB pada interneuron parvalbumin di korteks visual primer. Oleh karena itu, data kami menunjukkan bahwa meskipun PSA-NCAM meregulasi sirkuit inhibitorik, molekul ini tidak diperlukan untuk reaktivasi plastisitas serupa-juvenil yang dipicu oleh Fluoxetine.
Reference Key
eguirado2016frontierseffects Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ramon eGuirado, Danilo eLa Terra, Mathieu eBourguignon, Hector eCarceller, Juzoh eUmemori, Pia eSipilä, Juan eNacher, Eero eCastren
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Journal macromolecular bioscience
Year 2016
DOI
10.3389/fncel.2016.00022
URL
http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00022/full
Keywords
fluoxetine neuropsychiatry biological psychiatry

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