simple and sensitive method for determination of polyhexanide in multipurpose solution
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ID: 183602
2009
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Abstract
A simple reversed phase HPLC method has been developed for the determination of polyhexamethylene biguanide hydrochloride in multipurpose solution for hydrophilic contact lenses. The mobile phase was acetonitrile 1% (v/v) ammonium acetate 20 mM in water as 16: 84 (v/v) at a flow rate of 1 ml / min. Polyhexamethylene biguanide hydrochloride was detected by UV absorption at 235 nm. The pH was kept at 4.0 using glacial acetic acid. The method of Yiping et al has been slightly modified as needed. The quantity detected was 2 µg/ml so it was carried out using a preconcentration method under vaccum. From the chromatogram, it was observed that a distinct peak appeared at retention time 5.883 min for polyhexamethylene biguanide hydrochloride. The recovery of drug was found to be 99.38% and the method was simple, rapid and suitable for the assay of drug in multipurpose solution for hydrophilic contact lenses and for carrying out stability as per ICH guidelines to assess the stability of polyhexamethylene biguanide hydrochloride in multipurpose solution.
| Reference Key |
zzaman2009electronicsimple
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| Authors | ;M. T. Zzaman;A. Ali;A. Arora |
| Journal | animal models and experimental medicine |
| Year | 2009 |
| DOI |
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| Keywords | Keywords not found |
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