oral mite anaphylaxis caused by mite-contaminated okonomiyaki/pancake-mix in japan: 8 case reports and a review of 28 reported cases

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ID: 183592
2014
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Abstract
Background: Anaphylaxis after the ingestion of foods contaminated with mites has recently been recognized. Case series and case reports thus far have shown that mite-contaminated wheat flour is the major cause of oral mite anaphylaxis. However, we have found 8 cases of oral mite anaphylaxis which were caused by mitecontaminated okonomiyaki-mix, a savory Japanese style pancake mix, in our hospital. Methods: In addition to our 8 cases, the databases of MEDLINE and ICHUSHI were systematically searched for patients with oral mite anaphylaxis in Japan. Results: Thirty-six patients including our 8 cases with oral mite anaphylaxis were identified. Thirty-four out of 36 cases (94%) ingested okonomiyaki or takoyaki, prepared at home using okonomiyaki-mix or takoyaki-mix which was previously opened and stored for months at ambient temperature. Microscopic examination of culprit mixes of 16 cases including our 1 case revealed contamination of mites such as Dermatophagoides farina (Der f) (5 cases), Tyrophagus putrescentiae (Tyr p) (4 cases), and Dermatophagoides pteronyssinus (Der p) (3 cases). The specific IgE to each mite is generally upregulated in these patients. Especially, the titers of specific IgE to Der p and Der f were more than class 2 in all cases. Conclusions: Mite-contaminated flavored flour is the major cause of oral mite anaphylaxis in Japan.
Reference Key
takahashi2014allergologyoral Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Kentaro Takahashi;Masami Taniguchi;Yuma Fukutomi;Kiyoshi Sekiya;Kentaro Watai;Chihiro Mitsui;Hidenori Tanimoto;Chiyako Oshikata;Takahiro Tsuburai;Naomi Tsurikisawa;Kenji Minoguchi;Hiroshi Nakajima;Kazuo Akiyama
Journal current drug discovery technologies
Year 2014
DOI
10.2332/allergolint.13-OA-0575
URL
http://www.sciencedirect.com/science/article/pii/S1323893015300083
Keywords
food allergy japan anaphylaxis mite allergy

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