dactilitis and oligoarthritis after bcg immunotherapy in a patient affected by bladder cancer
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ID: 183500
2011
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Abstract
The treatment of bladder cancer with Bacillus of Calmette-Guerin (BCG) immunotherapy can induce the appearance of a reactive disorder. The Authors describe a 55-year-old male patient with bladder cancer treated with endovesical instillation of BCG immunotherapy, followed after the fifth application by asymmetric oligoarthritis and dactilitis. The observed positivity of both HLA-B27 and HLA-B51 antigens reinforces the hypothesis of a reactive form, possibly through "molecular mimicry" mechanism. The discontinuation of BCG instillation along which a therapeutic attempt with NSAD failed to improve the rheumatic manifestation, which completely remitted after a four-month course of oral steroids. No relapses of joint and tendon involvement was observed during the following five-month period. The clinico- pathogenetic implications suggested by this case are discussed.
| Reference Key |
elkhaldi2011reumatismodactilitis
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|---|---|
| Authors | ;N. Elkhaldi;L. Bernardini;C.U. Manzini;M.T. Mascia;C. Ferri |
| Journal | advances in civil engineering |
| Year | 2011 |
| DOI |
10.4081/reumatismo.2006.230
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| URL | |
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