regulation of tgf-β superfamily signaling by smad mono-ubiquitination

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ID: 182877
2014
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Abstract
TGF-β(transforming growth factor-β) superfamily signaling mediators are important regulators of diverse physiological and pathological events. TGF-β signals are transduced by transmembrane type I and type II serine/threonine kinase receptors and their downstream effectors, the SMAD(drosophila mothers against decapentaplegic protein) proteins. Numerous studies have already demonstrated crucial regulatory roles for modification of TGF-β pathway components by poly-ubiquitination. Recently, several studies also uncovered mono-ubiquitination of SMADs as a mechanism for SMAD activation or inactivation. Mono-ubiquitination and subsequent deubiquitination of SMAD proteins accordingly play important roles in the control of TGF-β superfamily signaling. This review highlights the major pathways regulated by SMAD mono-ubiquitination.
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xie2014cellsregulation Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Feng Xie;Zhengkui Zhang;Hans van Dam;Long Zhang;Fangfang Zhou
Journal Frontiers in psychology
Year 2014
DOI
10.3390/cells3040981
URL
http://www.mdpi.com/2073-4409/3/4/981
Keywords
tgf-β bmp smad

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