gaba-b receptors in the pns have a role in schwann cells differentiation?

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ID: 181961
2013
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Abstract
GABA-B receptor mediates the inhibitory transmission of -aminobutyric acid in the mammalian nervous system, being present in neurons and also in glial cells. Recently the presence of GABA-B has been demonstrated in Schwann cells suggesting its contribution in regulating the cell fate, maturation and plasticity. Here, we further support the functional presence of GABA-B receptor in Schwann cells plasma membrane. By confocal microscopy immunofluorescence we provide evidences that GABA-B localization on the cell elongated processes correlates with the morphological changes occurring in the differentiated Schwann cells. In vivo most of the GABA-B receptors seem to be present in non-myelinating Schwann cells, which are committed to en-sheet the nociceptive fibers. Therefore, we argue that GABA-B receptors do not control exclusively the in vivo differentiation yielding the myelinating Schwann cells, but are also fundamental in regulating the Schwann cells plasticity versus the non-myelinating state.Data from the literature and our recent findings corroborate the role of the GABAergic system and GABA-B receptors in the peripheral nervous system, opening new perspectives on the mechanisms controlling the differentiation of Schwann cells
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Authors ;Patrizia eProcacci;Marinella eBallabio;Luca Franco Castelnovo;Cristina Maria Mantovani;Valerio eMagnaghi
Journal macromolecular bioscience
Year 2013
DOI
10.3389/fncel.2012.00068
URL
http://journal.frontiersin.org/Journal/10.3389/fncel.2012.00068/full
Keywords
gaba peripheral nervous system camp actin myelin neuropsychiatry biological psychiatry

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