prognostic impacts of hypoxic markers in soft tissue sarcoma

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ID: 181799
2012
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Abstract
Background. We aimed to explore the prognostic impact of the hypoxia-induced factors (HIFαs) 1 and 2, the metabolic HIF-regulated glucose transporter GLUT-1, and carbonic anhydrase IX (CAIX) in non-gastrointestinal stromal tumor soft tissue sarcomas (non-GIST STS). Methods. Duplicate cores with viable tumor tissue from 206 patients with non-GIST STS were obtained and tissue microarrays were constructed. Immunohistochemistry (IHC) was used to evaluate expression of hypoxic markers. Results. In univariate analyses, GLUT-1 (P<0.001) and HIF-2α (P=0.032) expression correlated significantly with a poor disease-specific survival (DSS). In the multivariate analysis, however, only high expression of GLUT-1 (HR 1.7, CI 95% 1.1–2.7, P=0.021) was a significant independent prognostic indicator of poor DSS. Conclusion. GLUT-1 is a significant independent negative prognostic factor in non-GIST STS.
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smeland2012sarcomaprognostic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Eivind Smeland, Thomas K. Kilvaer, Sveinung Sorbye, Andrej Valkov, Sigve Andersen, Roy M. Bremnes, Lill-Tove Busund, Tom Donnem
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Journal the journal of physiology
Year 2012
DOI
10.1155/2012/541650
URL
http://dx.doi.org/10.1155/2012/541650
Keywords
neoplasms Oncology including cancer and carcinogens tumors

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