prognostic impacts of hypoxic markers in soft tissue sarcoma
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ID: 181799
2012
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Abstract
Background. We aimed to explore the prognostic impact of the hypoxia-induced factors (HIFαs) 1 and 2, the metabolic HIF-regulated glucose transporter GLUT-1, and carbonic anhydrase IX (CAIX) in non-gastrointestinal stromal tumor soft tissue sarcomas (non-GIST STS).
Methods. Duplicate cores with viable tumor tissue from 206 patients with non-GIST STS were obtained and tissue microarrays were constructed. Immunohistochemistry (IHC) was used to evaluate expression of hypoxic markers.
Results. In univariate analyses, GLUT-1 (P<0.001) and HIF-2α (P=0.032) expression correlated significantly with a poor disease-specific survival (DSS). In the multivariate analysis, however, only high expression of GLUT-1 (HR 1.7, CI 95% 1.1–2.7, P=0.021) was a significant independent prognostic indicator of poor DSS.
Conclusion. GLUT-1 is a significant independent negative prognostic factor in non-GIST STS.
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| Reference Key |
smeland2012sarcomaprognostic
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|---|---|
| Authors | ;Eivind Smeland;Thomas K. Kilvaer;Sveinung Sorbye;Andrej Valkov;Sigve Andersen;Roy M. Bremnes;Lill-Tove Busund;Tom Donnem |
| Journal | the journal of physiology |
| Year | 2012 |
| DOI |
10.1155/2012/541650
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| URL | |
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