c-myc—making liver sick: role of c-myc in hepatic cell function, homeostasis and disease

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ID: 181685
2017
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Abstract
Over 35 years ago, c-MYC, a highly pleiotropic transcription factor that regulates hepatic cell function, was identified. In recent years, a considerable increment in the number of publications has significantly shifted the way that the c-MYC function is perceived. Overexpression of c-MYC alters a wide range of roles including cell proliferation, growth, metabolism, DNA replication, cell cycle progression, cell adhesion and differentiation. The purpose of this review is to broaden the understanding of the general functions of c-MYC, to focus on c-MYC-driven pathogenesis in the liver, explain its mode of action under basal conditions and during disease, and discuss efforts to target c-MYC as a plausible therapy for liver disease.
Reference Key
zheng2017genesc-mycmaking Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Kang Zheng;Francisco Javier Cubero;Yulia A. Nevzorova
Journal thermal science and engineering progress
Year 2017
DOI
10.3390/genes8040123
URL
http://www.mdpi.com/2073-4425/8/4/123
Keywords
hepatocellular carcinoma hepatitis c virus hepatitis b virus alcoholic liver disease

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