mir-203 facilitates tumor growth and metastasis by targeting fibroblast growth factor 2 in breast cancer

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ID: 181433
2016
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Abstract
Shuqian He, Guihui Zhang, He Dong, Maoqiang Ma, Qing Sun Department of Pathology, Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong, People’s Republic of China Abstract: Breast cancer is the second leading cause of cancer mortality in women worldwide. Molecular therapy is needed to improve the outcome in patients with breast cancer. miR-203 participates in cancer cell proliferation, transformation, and apoptosis. This study showed that miR-203 was upregulated in breast cancer tissues and the MCF-7 cell line. miR-203 knockdown suppressed colony formation and transformation and also limited migration in MCF-7 cells. Fibroblast growth factor 2 (FGF2) was confirmed as a novel target of miR-203, as miR-203 knockdown induced an enhanced expression of FGF2 in MCF-7 cells. Moreover, FGF2 can reverse transforming growth factor-β signal pathway to suppress breast cancer. These findings provide new insights with potential therapeutic applications for the treatment of breast cancer. Keywords: breast cancer, miR-203, FGF2
Reference Key
s2016oncotargetsmir-203 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors He S, Zhang G, Dong H, Ma M, Sun Q
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Journal jurnal tam
Year 2016
DOI
DOI not found
URL
https://www.dovepress.com/mir-203-facilitates-tumor-growth-and-metastasis-by-targeting-fibroblas-peer-reviewed-article-OTT
Keywords
Breast cancer Oncology including cancer and carcinogens tumors

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