the role of il-22 in viral infections: paradigms and paradoxes
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ID: 180711
2016
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Abstract
Interleukin-22 (IL-22) is a member of the IL-10 family of cytokines. Hematopoietic cells express IL-22, and this cytokine signals through the heterodimeric IL-22R expressed by non-hematopoietic cells. A growing body of evidence points towards a role for IL-22 in a diverse array of biological functions ranging from cellular proliferation, tissue protection and regeneration, and inflammation. In recent years, the role that IL-22 plays in antiviral immune responses has been examined in a number of infection models. Herein, we assess our current understanding of how IL-22 determines the outcome of viral infections and define common mechanisms that are evident from, sometimes paradoxical, findings derived from these studies. Finally, we discuss the potential therapeutic utility of IL-22 manipulation in the treatment and prevention of viral infections and associated pathologies.
| Reference Key |
brias2016frontiersthe
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| Authors | ;Silvia eGimeno Brias;Gabrielle eStack;Maria A Stacey;Alec J Redwood;Ian R Humphreys |
| Journal | sudebno-meditsinskaia ekspertiza |
| Year | 2016 |
| DOI |
10.3389/fimmu.2016.00211
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