actn3 gene and sports performance: a candidate gene to success in short and long duration events. 10.5007/1980-0037.2011v13n6p477

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ID: 180418
2011
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Abstract
The aim of the present study was to review the evidence on the relationship between the R577X polymorphism of the ACTN3 gene and sports performance. The Pubmed database was searched using ACTN3 gene AND sports performance as keywords. The ACTN3 gene encodes a muscle-specific protein, called α-actinin-3, which is only present in type II fibers. Most studies have demonstrated a relationship between the presence of α-actinin-3 and the ability of muscle to generate force. However, recent studies suggest that the absence of the functional form of this protein may regulate substrate utilization during exercise, giving priority to oxidative metabolism, sparing muscle glycogen, and improving performance in long-duration events. Nevertheless, further studies involving humans are needed to better understand the metabolic role of this protein.
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pasqua2011revista<b>actn3 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Leonardo Alves Pasqua;Guilherme Giannini Artioli;Flávio de Oliveira Pires;Rômulo Cássio de Moraes Bertuzzi
Journal journal of proteome research
Year 2011
DOI
DOI not found
URL
http://www.periodicos.ufsc.br/index.php/rbcdh/article/view/18904/19623
Keywords
genetics aerobic metabolism sportsmedicine (general)

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