proteomic insights into non-small cell lung cancer: new ideas for cancer diagnosis and therapy from a functional viewpoint

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ID: 179665
2014
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Abstract
We recently characterized SEC62 as an oncogene in non-small-cell lung cancer (NSCLC). Here we aimed to gain further insight into the molecular mechanisms of the cancer-related functions of this oncogene. We performed 2D-DIGE proteome analysis of tumor material from patients with NSCLC and of HEK293 cells stably overexpressing plasmid-encoded SEC62, combined with investigation of the Sec62 interactome. Furthermore, we analyzed the proteomic effects of siRNA-mediated depletion of the Sec62-interacting protein Sec63. We identified a comprehensive list of differentially regulated proteins, providing new insights into the molecular mechanisms of the cancer-related functions of Sec62 in cell migration, drug resistance, and Ca2+-homeostasis.
Reference Key
linxweiler2014eupaproteomic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Johannes Linxweiler;Laxmikanth Kollipara;René P. Zahedi;Pavel Lampel;Richard Zimmermann;Markus Greiner
Journal technological and economic development of economy
Year 2014
DOI
10.1016/j.euprot.2014.05.004
URL
http://www.sciencedirect.com/science/article/pii/S2212968514000373
Keywords
non-small cell lung cancer (nsclc) vimentin 2d-dige

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