weighted gene co-expression network analysis reveals dysregulation of mitochondrial oxidative phosphorylation in eating disorders

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ID: 179663
2018
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Ranked #62 of 86 articles by views in thermal science and engineering progress

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Abstract
The underlying mechanisms of eating disorders (EDs) are very complicated and still poorly understood. The pathogenesis of EDs may involve the interplay of multiple genes. To investigate the dysregulated gene pathways in EDs we analyzed gene expression profiling in dorsolateral prefrontal cortex (DLPFC) tissues from 15 EDs cases, including 3 with anorexia nervosa (AN), 7 with bulimia nervosa (BN), 2 AN-BN cases, 3 cases of EDs not otherwise specified, and 102 controls. We further used a weighted gene co-expression network analysis to construct a gene co-expression network and to detect functional modules of highly correlated genes. The functional enrichment analysis of genes in co-expression modules indicated that an altered mitochondrial oxidative phosphorylation process may be involved in the pathogenesis of EDs.
Reference Key
yang2018genesweighted Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Liulin Yang;Yun Li;Turki Turki;Huizi Tan;Zhi Wei;Xiao Chang
Journal thermal science and engineering progress
Year 2018
DOI
10.3390/genes9070325
URL
http://www.mdpi.com/2073-4425/9/7/325
Keywords
eating disorders

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