cellular and molecular mechanisms of chronic kidney disease with diabetes mellitus and cardiovascular diseases as its comorbidities

Clicks: 221
ID: 179445
2015
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #512 of 644 articles by views in sudebno-meditsinskaia ekspertiza

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 644 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Chronic kidney disease (CKD), diabetes mellitus (DM) and cardiovascular diseases (CVD) are complex disorders of partly unknown genesis and mostly known progression factors. CVD and DM are the risk factors of CKD and are strongly intertwined since DM can lead to both CKD and/or CVD and CVD can lead to kidney disease. In recent years our knowledge of CKD, DM and CVD has been expanded and several important experimental, clinical and epi-demiological associations have been reported. The tight cellular and molecular interactions between the renal, diabetic and cardiovascular systems in acute or chronic disease settings is becoming increasingly evident. However, the (patho-) physiological basis of the interactions of CKD, DM and CVD with involvement of multiple endogenous and environmental factors is highly complex and our knowledge still at its infancy. Not only single pathways and media-tors of progression of these diseases have to be considered in these processes, but also the mutual interactions of these factors are essential. The recent advances in proteomics and inte-grative analysis technologies have allowed rapid progress in analyzing complex disorders and clearly show the opportunity for new efficient and specific therapies. More than a dozen pathways have been identified so far, including hyperactivity of the renin-angiotensin-aldosterone system, osmotic sodium retention, endothelial dysfunction, dyslipidemia, RAS/RAF/ERK pathway, modification of the purinergic system, phosphatidylinositol 3-kinase (PI 3-kinase)-dependent signaling pathways, andinflammation, all leading to histomor-phological alterations of the kidney and vessels of diabetic and non-diabetic patients. Since a better understanding of the common cellular and molecular mechanisms of these diseases may be a key to successful identification of new therapeutic targets, we review in this paper the current literature about cellular and molecular mechanisms of CKD.
Reference Key
gajjala2015frontierscellular Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Prathibha Reddy Gajjala;Joachim eJankowski;Maryam eSanati
Journal sudebno-meditsinskaia ekspertiza
Year 2015
DOI
10.3389/fimmu.2015.00340
URL
http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00340/full
Keywords
inflammation diabetes mellitus cardiovascular diseases fibrosis allergy

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.