Systematic Diversity-Oriented Synthesis of Reduced Flavones from γ-Pyrones to Probe Biological Performance Diversity.

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ID: 1786
2019
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Abstract
Diversity-oriented synthesis (DOS) has historically focused on the development of small-molecule collections with considerable chemical diversity with the hypothesis that chemical diversity will lead to diverse biological activities. We took a systematic approach to DOS to develop a focused library of reduced flavones from γ-pyrones with diversity of appendage, stereochemistry, and chemical properties to determine which features of small molecules are most predictive of biological performance diversity. The effects of these systematic modifications on biodiversity were determined using Cell Painting and cytotoxicity assays to compare the results of multiple methods of assessment. We observed that a greater fraction of sp hybridized atoms (fsp) does not always lead to enhanced biodiversity, that stereochemistry and appendage diversity both contribute to biodiversity, and that lipophilicity of the pyrone class of compounds correlates with biodiversity. These results will contribute to the development of a general algorithm to predict which chemical features should be considered during the synthesis of DOS libraries to create biological performance-diverse collections of small molecules for probe and drug discovery.
Reference Key
gerlach2019systematicacs Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Gerlach, Erica M;Korkmaz, Melissa A;Pavlinov, Ivan;Gao, Qiwen;Aldrich, Leslie N;
Journal ACS chemical biology
Year 2019
DOI
10.1021/acschembio.9b00294
URL
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