mecanismos moleculares implicados en las enfermedades cardiovasculares aterotrombóticas molecular mechanisms involved in atherothrombotic cardiovascular disease

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ID: 178570
2012
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Abstract
El síndrome coronario agudo es un problema de salud y constituye la primera causa de muerte en el mundo desarrollado y en Cuba. Esta enfermedad, que incluye infarto de miocardio, angina de pecho y muerte súbita, causa más muertes cada año que el resto de las enfermedades combinadas. El factor causal de mayor relevancia del infarto del miocardio, radica en la formación y evolución crónica de un ateroma, o eventos que son favorecidos por el estrés oxidativo, las citocinas proinflamatorias, la trombina y el no control de los factores de riesgo. La presente revisión se realizó con el propósito de explicar los mecanismos moleculares y la influencia de los factores de riesgo implicados en la fisiopatología de estas enfermedades. Se concluyó que las especies reactivas del oxígeno y el estrés oxidativo, desempeñan un papel importante en la fisiopatología de estas afecciones cardiovasculares, de relevancia para el diagnóstico y la terapéutica.
Acute coronary syndrome is a health problem and is the leading cause of death in Europe, North America, and Cuba. This disease, which includes heart attack, angina and sudden death, causes more deaths each year than all other diseases combined. The most important causal factor of myocardial infarction lies in the formation and chronic evolution of atheroma, or events that are favored by oxidative stress, proinflammatory cytokines, thrombin and no control of risk factors. This review was conducted in order to explain the molecular mechanisms and the influence of the risk factors involved in the pathophysiology of these diseases. It was concluded that reactive oxygen species and oxidative stress play an important role in the pathophysiology of such cardiovascular disorders, of relevance for its diagnosis and therapy.
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Authors ;Judith Borrero Sánchez;Ela María Céspedes Miranda;Marisol Peña Sánchez;Niurelkis Suárez Castillo;Reison Adalberto Olivero Betancourt
Journal chemical biology and drug design
Year 2012
DOI
DOI not found
URL
http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-21252012000300008
Keywords
oxidative stress reactive oxygen species

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