detection of membrane fluidity in submitochondrial particles of platelets and erythrocyte membranes from mexican patients with alzheimer disease by intramolecular excimer formation of 1,3 dipyrenylpropane
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ID: 178111
2008
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Abstract
It has been suggested that mitochondrial dysfunction and defects in membrane structure could be implied in AD pathogenesis. The aim of the present work was the study of membrane fluidity in submitochondrial platelet particles and erythrocyte membranes from Mexican patients. Blood samples were obtained from 30 patients with Alzheimer disease and 30 aged-matched control subjects. Membrane fluidity determinations were done using a very low concentration of the fluorescent dipyrenylpropane probe incorporated in both types of membranes. This probe is able to give excimer and monomer fluorescence, therefore it can be used to monitor fluidity changes in biological membranes.
| Reference Key |
ortiz2008diseasedetection
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|---|---|
| Authors | ;G.G. Ortiz;F. Pacheco-Moisés;M. El Hafidi;A. Jiménez-Delgado;M. A. Macías-Islas;S. A. Rosales Corral;A. Célis de la Rosa;V. J. Sánchez-González;E. D. Arias-Merino;I. E. Velázquez-Brizuela |
| Journal | international journal of psychology : journal international de psychologie |
| Year | 2008 |
| DOI |
10.1155/2008/642120
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| URL | |
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