b cell help by cd1d-rectricted nkt cells

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ID: 177980
2015
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Abstract
B cell activation and antibody production against foreign antigens is a central step of host defense. This is achieved via highly regulated multi-phase processes that involve a variety of cells of both innate and adaptive arms of the immune system. MHC class II-restricted CD4+ T cells specific for peptide antigens, which acquire professional follicular B cell helper functions, have been long recognized as key players in this process. Recent data, however, challenge this paradigm by showing the existence of other helper cell types. CD1d restricted NKT cells specific for lipid antigens are one such new player and can coopt bona fide follicular helper phenotypes. Their role in helping antigen-specific B cell response to protein antigens, as well as to the so called “help-less” antigens that cannot be recognized by T follicular helper cells, is being increasingly elucidated, highlighting their potential pathophysiological impact on the immune response, as well as on the design of improved vaccine formulations.
Reference Key
clerici2015antibodiesb Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Livia Clerici;Giulia Casorati;Paolo Dellabona
Journal analytical methods
Year 2015
DOI
10.3390/antib4040279
URL
http://www.mdpi.com/2073-4468/4/4/279
Keywords
allergy

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