angiosarcoma of the retroperitoneum: report on a patient treated with sunitinib

Clicks: 128
ID: 177843
2009
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Abstract
A 52 year-old woman presented with an incidentally detected retroperitoneal angiosarcoma and multiple hepatic metastases. After chemotherapy with weekly paclitaxel and doxorubicin, angiosarcoma had progressed rapidly. Because few chemotherapeutic options were available for her, sunitinib (37.5 mg/day, daily) as a salvage regimen was administered. Although sunitinib was interrupted after two weeks due to hematologic abnormalities, some metastatic nodules were regressed. Therefore, sunitinib was recommenced at a reduced dose (25 mg/day, daily). Serial computed tomography scans showed variable response in each tumor, however, sunitinib at least delayed tumor progression, compared to previous chemotherapy. With this case report, we suggest sunitinib may be effective against angiosarcomas. When sunitinib is administered to patients with angiosarcomas, hematologic abnormalities should be monitored frequently as severe hematologic toxicity may be caused either by sunitinib per se or angiosarcoma.
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yoo2009sarcomaangiosarcoma Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Changhoon Yoo;Jeong-Eun Kim;Shin-Kyo Yoon;Song Cheol Kim;Jin-Hee Ahn;Tae Won Kim;Cheolwon Suh;Jae-Lyun Lee
Journal the journal of physiology
Year 2009
DOI
10.1155/2009/360875
URL
http://dx.doi.org/10.1155/2009/360875
Keywords
neoplasms Oncology including cancer and carcinogens tumors

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