dosing strategy based on prevailing aminoglycoside minimum inhibitory concentration in india: evidence and issues
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ID: 176924
2017
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Abstract
Aminoglycosides are important agents used for treating drug-resistant infections. The current dosing regimen of aminoglycosides does not achieve sufficient serum level concentration for the infected bacterial pathogen interpreted as susceptible based on laboratory testing. Minimum inhibitory concentration was determined for nearly 2000 isolates of Enterobacteriaceae and Pseudomonas aeruginosa by broth microdilution method. Results were interpreted based on CLSI and EUCAST interpretative criteria and the inconsistencies in the susceptibility profile were noted. This study provides insights into the inconsistencies existing in the laboratory interpretation and the corresponding clinical success rates. This urges the need for revising clinical breakpoints for amikacin, to resolve under dosing leading to clinical failure.
| Reference Key |
veeraraghavan2017indiandosing
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|---|---|
| Authors | ;Balaji Veeraraghavan;Agila Kumari Pragasam;Abi Manesh;Priscilla Rupali;Ramya Iyadurai;Camilla Rodrigues;Sangeeta Joshi;Indranil Roy;Bhaskar Narayan Chaudhuri;D S Chitnis;Dhole Tapan |
| Journal | bjog : an international journal of obstetrics and gynaecology |
| Year | 2017 |
| DOI |
10.4103/ijmm.IJMM_17_386
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| URL | |
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