a retrospective analysis of vinorelbine chemotherapy for patients with previously treated soft-tissue sarcomas
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2006
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Abstract
Introduction. The role of vinorelbine in specific soft tissue sarcoma subtypes is unclear. We present retrospective single institution experience with single-agent vinorelbine in subjects with metastatic soft tissue malignancies. Methods. Fifty-eight patients were treated with single agent intravenous vinorelbine between April 1997 and December 2004. Doxorubicin had been administered previously to 53 subjects
(91%), and the median number of lines of previous chemotherapy was 3 (range 0–7). Results. Patients received a median 6 doses of vinorelbine (range 1–65). The overall response rate was 6% (3 patients: 1 angiosarcoma, 1 epithelioid sarcoma, and 1
embryonal rhabdomyosarcoma). Fourteen patients (26%) experienced a best result of
stable disease. Median time to progression was 1.8 months (95% confidence intervals
1.5–2.1 months, Kaplan-Meier estimate). Eight patients experienced grade 3 or 4 toxicity,
most commonly febrile neutropenia. Conclusion. Vinorelbine demonstrates limited activity in a heavily pretreated
group of soft-tissue sarcoma patients. Prospective investigation may be considered for selected sarcoma
subtypes.
| Reference Key |
anderson2006sarcomaa
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|---|---|
| Authors | ;Sibyl E. Anderson;Mary L. Keohan;David R. D'Adamo;Robert G. Maki |
| Journal | the journal of physiology |
| Year | 2006 |
| DOI |
10.1155/SRCM/2006/15947
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| URL | |
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