an unusual case of splenomegaly and increased lactate dehydrogenase heralding acute myeloid leukemia with eosinophilia and runx1–mecom fusion transcripts

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ID: 175915
2014
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Abstract
We report the first case of acute myeloid leukemia (AML) with RUNX1–MECOM fusion transcripts, showing marked eosinophilia. A 63-year old man admitted in August 2013, had previously been observed in April 2013, because of persisting homogeneous splenomegaly and increased LDH, which were initially attributed to both minor β-thalassemia and previous acute myocardial infarction. However, based upon the retrospective analysis of clinical features combined with the documentation of both JAK2 V617F and c-KIT D816V mutations at AML diagnosis, an aggressive leukemic transformation with eosinophilia of a previously unrecognized myeloproliferative neoplasm, rather than the occurrence of de novo AML, may be hypothesized.
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forghieri2014leukemiaan Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Fabio Forghieri;Sara Bigliardi;Monica Morselli;Leonardo Potenza;Valeria Fantuzzi;Laura Faglioni;Vincenzo Nasillo;Andrea Messerotti;Ambra Paolini;Mario Luppi
Journal urology annals
Year 2014
DOI
10.1016/j.lrr.2014.09.003
URL
http://www.sciencedirect.com/science/article/pii/S2213048914000211
Keywords
acute myeloid leukemia eosinophilia Oncology including cancer and carcinogens tumors

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