an unusual case of splenomegaly and increased lactate dehydrogenase heralding acute myeloid leukemia with eosinophilia and runx1–mecom fusion transcripts
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2014
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Abstract
We report the first case of acute myeloid leukemia (AML) with RUNX1–MECOM fusion transcripts, showing marked eosinophilia. A 63-year old man admitted in August 2013, had previously been observed in April 2013, because of persisting homogeneous splenomegaly and increased LDH, which were initially attributed to both minor β-thalassemia and previous acute myocardial infarction. However, based upon the retrospective analysis of clinical features combined with the documentation of both JAK2 V617F and c-KIT D816V mutations at AML diagnosis, an aggressive leukemic transformation with eosinophilia of a previously unrecognized myeloproliferative neoplasm, rather than the occurrence of de novo AML, may be hypothesized.
| Reference Key |
forghieri2014leukemiaan
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| Authors | ;Fabio Forghieri;Sara Bigliardi;Monica Morselli;Leonardo Potenza;Valeria Fantuzzi;Laura Faglioni;Vincenzo Nasillo;Andrea Messerotti;Ambra Paolini;Mario Luppi |
| Journal | urology annals |
| Year | 2014 |
| DOI |
10.1016/j.lrr.2014.09.003
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