Digestibility in the gastrointestinal tract and migration to blood of β'-component (Onk k 5), a major salmon roe IgE-binding protein.

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ID: 1757
2019
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Abstract
The major allergen of chum salmon (Oncorhynchus keta) roe is the β'-component (Onc k 5, β'-c), which is a yolk protein and a fragment of vitellogenin. When yolk content containing β'-c was orally administered to mice, β'-c passed through the gastrointestinal tract and was excreted in feces without marked degradation. The direct administration of β'-c to ligated jejunal and ileal loops showed that β'-c was absorbed through the small intestine and transferred into the blood. Immunohistochemical staining showed that orally administered β'-c was distributed from the apical side to the basal side of intestinal epithelial cells, suggesting that endocytosis may be involved in the intestinal absorption of β'-c. In conclusion, β'-c is absorbed along a large portion of the small intestine and circulates in the blood stream without significant digestion. The resistance of β'-c to gastrointestinal digestion seems to contribute to its strong allergenicity.
Reference Key
kyosaka2019digestibilityfood Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kyosaka, Issei;Fujita, Shingo;Shimizu, Yutaka;Saeki, Hiroki;
Journal Food chemistry
Year 2019
DOI
S0308-8146(19)30567-9
URL
Keywords Keywords not found

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