role of factor xa inhibitors in cancer-associated thrombosis: any new data?

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ID: 173692
2011
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Abstract
The association between cancer and venous thromboembolism (VTE) has been well documented in the literature. Prevention and treatment of VTE in cancer patients is imperative. Typically, the mainstay regimen for VTE prevention and treatment has been anticoagulation therapy, unless contraindicated. This therapy consists of unfractionated heparin (UFH), low-molecular-weight heparin (LMWH), factor Xa inhibitor, or vitamin K antagonist (VKA). Current guidelines recommend LMWH over VKA for the treatment of VTE in cancer patients. Factor-specific anticoagulants have been proven safe and effective, and recently factor Xa inhibitors have emerged as a treatment alternative to heparins and VKA. Currently, three factor Xa inhibitors have been identified: fondaparinux (the only one approved so far by the US Food and Drug Administration), idraparinux (in clinical trials), and idrabiotaparinux (in clinical trials). This paper will examine the role of these agents, focusing on fondaparinux, for the prevention and treatment of VTE in cancer patients.
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zalpour2011advancesrole Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Ali Zalpour;Michael H. Kroll;Vahid Afshar-Kharghan;Syed Wamique Yusuf;Carmen Escalante
Journal the european journal of general practice
Year 2011
DOI
10.1155/2011/196135
URL
http://dx.doi.org/10.1155/2011/196135
Keywords
Diseases of the blood and blood-forming organs

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