Encryption and steganography of synthetic gene circuits.

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ID: 17364
2018
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Abstract
Synthetic biologists use artificial gene circuits to control and engineer living cells. As engineered cells become increasingly commercialized, it will be desirable to protect the intellectual property contained in these circuits. Here, we introduce strategies to hide the design of synthetic gene circuits, making it more difficult for an unauthorized third party to determine circuit structure and function. We present two different approaches: the first uses encryption by overlapping uni-directional recombinase sites to scramble circuit topology and the second uses steganography by adding genes and interconnections to obscure circuit topology. We also discuss a third approach: to use synthetic genetic codes to mask the function of synthetic circuits. For each approach, we discuss relative strengths, weaknesses, and practicality of implementation, with the goal to inspire further research into this important and emerging area.
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purcell2018encryptionnature Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Purcell, Oliver;Wang, Jerry;Siuti, Piro;Lu, Timothy K;
Journal Nature communications
Year 2018
DOI
10.1038/s41467-018-07144-7
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