application of forgetful analgesia induction in induction period in patients with obstructive jaundice

Objective　To observe the effect of forgetful analgesia induction and tracheal intubation on the hemodynamic changes in induction period in patients with obstructive jaundice, and explore a safe method for anesthesia induction and tracheal intubation. Methods　Sixty patients with obstructive jaundice undergoing elective abdominal operation in General Hospital of PLA from February, 2013 to August, 2013 were involved in the present study. Participants included 36 male and 24 female patients, aging 19-65 years (mean 42±5 years), weighing 47-73 kg (mean 54±6 kg), with ASA Ⅰ-Ⅱ. These 60 patients were randomly divided into forgetful analgesia induction-tracheal intubation group (group A, n=30) and rapid induction-tracheal intubation group (group B, n=30). The heart rate (HR), mean arterial pressure (MAP), pulse oxygen saturation (SpO2) at the time point of before induction (T0), before intubation (T1), at the moment of intubation (T2) and 3 min after intubation (T3) were determined in both groups. Administration times of ephedrine hydrochloride and atropine was recorded in both groups. Results　There was no significant difference in HR, MAP, SpO2 before and after induction in group A. In the patients of group B, the HR increased and MAP decreased after induction compared with those before induction (P<0.05), and the change of SpO2 was not significant. Ephedrine hydrochloride and atropine were administrated in both groups, and the cases and times of ephedrine hydrochloride administration were more in group B than in group A (P<0.05). Conclusion　The forgetful analgesia induction-tracheal intubation could effectively control the stress response and reduce the fluctuation in hemodynamics during induction of anesthesia in patients with obstructive jaundice. DOI: 10.11855/j.issn.0577-7402.2014.02.15