A novel thermo-responsive multiblock architecture composed of a sequential peptide and an amino acid-derived vinyl polymer: toward protein-mimicking single-chain folding.
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ID: 17206
2019
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Abstract
A novel multiblock architecture composed of an alternating β-sheet forming oligopeptide and a thermo-responsive glycine-derived vinyl polymer was synthesized. The polymer exhibited lower critical solution temperature (LCST) behavior in water, unlike the behavior of a glycine-derived homopolymer, and formed nanoparticles through protein-mimicking folding driven by thermal cycle-induced β-sheet formation.
| Reference Key |
nishimura2019achemical
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|---|---|
| Authors | Nishimura, Shin-Nosuke;Higashi, Nobuyuki;Koga, Tomoyuki; |
| Journal | Chemical communications (Cambridge, England) |
| Year | 2019 |
| DOI |
10.1039/c8cc09051c
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| URL | |
| Keywords | Keywords not found |
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