Towards Intelligent Integration and Sharing of Stem Cell Research Data.

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ID: 171817
2020
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Ranked #64 of 170 articles by views in Studies in health technology and informatics

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Abstract
Advancements in regenerative medicine have brought to the fore the need for increased standardization and sharing of stem cell product characterization to help drive these innovative interventions toward public availability. Although numerous attempts have been made to store this data, there is still a lack of a platform that incorporates heterogeneous stem cell information into a harmonized project-based framework. The aim of this project was to introduce and pilot-test an intelligent informatics solution which integrates diverse stem cell product characteristics with study subject and omics information. In the resulting platform, heterogeneous data is validated using predefined ontologies and stored in a NoSQL repository. Pilot-testing was performed on nine sponsored stem cell projects conducting preclinical and intervention evaluations. The pilot-testing demonstrated the robustness of the proposed platform, by seamlessly harmonizing diverse common data elements, and the potential of this platform for driving knowledge generation from the aggregation of this shared data.
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borziak2020towardsstudies Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Borziak, Kirill;Qi, Tianye;Evangelista, John Erol;Clarke, Daniel J B;Ma'ayan, Avi;Finkelstein, Joseph;
Journal Studies in health technology and informatics
Year 2020
DOI
10.3233/SHTI200563
URL
Keywords
stem cells regenerative medicine data aggregation common data elements

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