Thermo-responsive behaviors and bioactivities of hydroxybutyl chitosans prepared in alkali/urea aqueous solutions

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ID: 17175
2019
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Abstract
A series of hydroxybutyl chitosans (HBCSs) with a degree of substitution (DS) ranging from 0.38 to 1.54 were homogeneously synthesized in KOH/LiOH/urea aqueous solutions under ambient conditions. The structure and solution properties of HBCSs were characterized by FT-IR, NMR, SEC-LLS, UV-vis, rheological and DLS measurements. The amino groups at C2 and hydroxyl groups at C3 and C6 participated in the reaction, although substitution mainly occurred at the hydroxyl groups at C6. The HBCSs exhibited good solubility in aqueous solutions, and those with a DS above 1.25 displayed phase separation behavior and precipitated out from solution when heated to a critical temperature. All results confirmed the hypothesis that the homogeneous KOH/LiOH/urea aqueous solution is a stable, mild, and energy-saving reaction medium for preparing HBCSs. Moreover, the HBCSs exhibited excellent biocompatibility, and even promoted the proliferation of normal cells. They also displayed antibacterial activities against Staphylococcus aureus and Escherichia coli, thus being suitable for biomedical applications.
Reference Key
cai2019thermoresponsivecarbohydrate Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Cai, Y.
Journal Carbohydrate polymers
Year 2019
DOI
10.1016/j.carbpol.2019.03.044
URL
Keywords Keywords not found

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