[Determination of flavonoids constituents in epimedium total flavone capsule and research on its anti-osteoporosis activity].

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ID: 1715
2018
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Ranked #3 of 23 articles by views in Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

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Abstract
To develop a rapid resolution liquid chromatography (RRLC) method for the simultaneous determination of epimedoside A, epimedin A1, epimedin A, epimedin B, epimedin C, icariin, baohuosideⅡ, icarisideⅠ, sagittatoside B, 2"--rhamnosyl icarisideⅡ, and baohuosideⅠin epimedium total flavone capsule. At the same time, the effects of the above 11 compounds on osteogenic differentiation of MC3T3-E1 cells were investigated by detecting the content of alkaline phosphatase (AKP). The results showed that baohuoside Ⅱ had the highest activities, and both the activities of baohuoside Ⅱ and icariside Ⅰ were stronger than those of icariin.In this study, the content determination method of flavonoid glycosides was established, and the anti-osteoporosis effect of monomers was compared, providing technical support for the study of the pharmacodynamic and mechanism of Epimedium total flavone capsule.
Reference Key
xu2018determinationzhongguo Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Xu, Zhong-Kun;Yin, Hong-Mei;Li, Fang;Qin, Jian-Ping;Gu, Shao-Li;Wu, Yun;Wang, Zhen-Zhong;Xiao, Wei;
Journal Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Year 2018
DOI
10.19540/j.cnki.cjcmm.20180611.003
URL
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