changes of mmp-9 and il-1 β in serum and cerebrospinal-fluid in children with central nervous system infection
Clicks: 210
ID: 170995
2016
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Steady Performance
30.0
/100
210 views
45 readers
AI Quality Assessment
Not analyzed
Readership in this journal
SteadyRanked #49 of 96 articles by views in journal of communications
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Objective: To provide a new basis for the detection of the central nervous system
infection cases, we explored and compared the role of cerebrospinal-fluid (CSF), matrix
metalloproteinases 9 (MMP-9) and interleukin 1 (the level of IL -1 β) in the central nervous
system (CNS). Methods: Sixty cases of children acute central nervous system infection
were selected, including 30 cases of viral encephalitis children (VE) and 30 cases of purulent
meningitis children (PM). Forty cases of non-central nervous system infection children were
control group. The serum albumin (SA1b) of each group was detected by full-automatic
analysis instrument, and the CSF albumin (CA1b) was detected by immunoephelometry and
the albumin index (AQ) was accounted. ELISE was used to detect the levels of MMP-9 and
IL-1 β in serum and cerebrospinal-fluid. Results: The level of MMP-9 in the serum of groups
of VE, PM and control were (267.84 ± 91.88) μg/L, (488.98 ± 159.07) μg/L and (133.04 ±
31.68) μg/L, while in the CSF were (37.18 ± 17.78) μg/L, (117.9 ± 42.87) μg/L and (10.36 ±
5.43) μg/L; The level of IL-1 β in serum of groups of PM, VE and control were (19.69 ± 11.12)
ng/L, (24.37 ± 4.13) ng/L and (15.01 ± 3.89) ng/L, while in the CSF were (66.94 ± 10.65) ng/L,
(106.27 ± 12.79) ng/L and (49.98 ± 12.59) ng/L; The level of CAlb were (0.53 ± 0.15) g/L, (1.05
± 0.27) g/L and (0.17 ± 0.07) g/L and AQ were (13.75 ± 3.44), (26.99 ± 7.28) and (4.63 ± 2.04).
The PM, VE were respectively compared with the control, the levels of IL-1 β and MMP-9
in serum and CSF all increased, with statistically significant difference.The VE, compared
to the PM, the level of IL-1 β in serum and CSF all decreased, with statistically significant
difference; The level of MMP-9 in serum and CSF all decreased, with statistically significant
difference. The level of CA1b and AQ in the VE and PM all increased, with a statistically
significant difference. The level of MMP-9 and IL-1 β in serum and CSF of the PM and VE
were positive correlation relationship. Conclusion: The increasing of the levels of IL-1 β and
MMP-9 in serum and CSF, and the increasing of AQ in children with central nervous system
infection indicate that MMP-9 and IL-1 β may play a role in the pathophysiologic course of
blood-brain barrier impairment in the central nervous system infection.
| Reference Key |
jiao2016journalchanges
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Shu-Qin Jiao |
| Journal | journal of communications |
| Year | 2016 |
| DOI |
DOI not found
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.