herc ubiquitin ligases in cancer

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ID: 170976
2020
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Abstract
HERC proteins are ubiquitin E3 ligases of the HECT family. The HERC subfamily is composed of six members classified by size into large (HERC1 and HERC2) and small (HERC3–HERC6). HERC family ubiquitin ligases regulate important cellular processes, such as neurodevelopment, DNA damage response, cell proliferation, cell migration, and immune responses. Accumulating evidence also shows that this family plays critical roles in cancer. In this review, we provide an integrated view of the role of these ligases in cancer, highlighting their bivalent functions as either oncogenes or tumor suppressors, depending on the tumor type. We include a discussion of both the molecular mechanisms involved and the potential therapeutic strategies.
Reference Key
sala-gaston2020cancersherc Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Joan Sala-Gaston;Arturo Martinez-Martinez;Leonardo Pedrazza;L. Francisco Lorenzo-Martín;Rubén Caloto;Xosé R. Bustelo;Francesc Ventura;Jose Luis Rosa
Journal The Journal of investigative dermatology
Year 2020
DOI
10.3390/cancers12061653
URL
https://www.mdpi.com/2072-6694/12/6/1653
Keywords
genome stability e3 tumor suppressor Oncology including cancer and carcinogens tumors

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