sarcoidosis: is there a role for anti-tnf-α?

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ID: 170972
2007
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Abstract
In severe cases of sarcoidosis treatment can be very difficult. The common treatment strategies might be failing. Tumour necrosis factor (TNF) α therapy is approved in rheumatoid arthritis, M. Crohn, psoriasis and ankylosing spondylitis. In sarcoidosis more recently a phase 2, multicenter, randomized, double-blind, placebo-controlled study was conducted in 138 patients with chronic sarcoidosis with pulmonary involvement. Patients in the combined infliximab groups (3 and 5 mg/kg) had a statistically significant improvement of the FVC (mean increase of 2.5% from baseline to week 24 in the percent of predicted FVC, compared with no change in placebo-treated patients (p=0.038)). Studies in the earlier mentioned diseases revealed that inadequate treatment responses could result from incomplete suppression of TNF α activity. This suggests that increasing patients’ dose or frequency of infliximab could in turn improve their clinical response. Further evaluation of anti-TNF therapy in symptomatic patients with severe, chronic sarcoidosis is needed. Key-words: Sarcoidosis, tumour necrosis factor, TNF-α, infliximab
Reference Key
drent2007revistasarcoidosis: Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Marjolein Drent
Journal the journal of applied psychology
Year 2007
DOI
DOI not found
URL
http://www.sciencedirect.com/science/article/pii/S0873215915304049
Keywords
diseases of the respiratory system

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