a green method for synthesis of 7h-thiazolo[3,2-b][1,2, 4]-triazin-7-one derivatives as ache inhibitors
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ID: 169053
2015
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Abstract
The authors study an efficient and green approach for the synthesis of 7H-thiazolo [3, 2-b][1,2,4]triazin-7-one derivatives as AChE inhibitors. The 7H-thiazolo[3,2-b][1,2,4]triazin-7-ones were designed by molecular docking, and readily prepared via a one-pot reaction in morpholine hydrosulfate ([Hnhm]HSO4) lonic liquid as the catalyst and solvent. The study of AChE inhibitory activity was carried out through using the Ellman colorimetric assay. The 7H-thiazolo[3,2-b][1,2,4]triazin-7-ones had been successfully synthesized by green catalyst. Most of the target compounds exhibited more than 50% inhibition at 10μM.
| Reference Key |
sijie2015mateca
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|---|---|
| Authors | ;Liu Sijie;Zhang Baohua;Jia Pengfei;Niu Nan;He Jingyu;Shi Lanxiang |
| Journal | acta botânica brasílica |
| Year | 2015 |
| DOI |
10.1051/matecconf/20152502002
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| URL | |
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