cross-talks between natural killer cells and distinct subsets of dendritic cells

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ID: 168884
2014
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Abstract
In recent years, the essential role of bidirectional cross-talk between natural killer (NK) and dendritic cells (DC) during immune responses has been clearly elucidated. In particular, this cross-talk results in the development of an efficient innate response, through DC-mediated NK cell activation, and a potent adaptive immune response, through NK-mediate DC editing and maturation.
Recently, some novel human DC subsets have been identified: migratory DCs in afferent lymph and draining lymph nodes; CLEC9A+/ BDCA3+ DCs in interstitial dermis, liver, lung; inflammatory DCs in several fluids secondary to flogosis. At the same time, it has been shown that also human NK cells are present in these compartments.
Here we will review the most recent findings on NK/DC cross-talk and we will discuss the necessity of acquiring more complete knowledge about these interactions in view of the new information available on both DC and NK cell subsets.
Reference Key
eferlazzo2014frontierscross-talks Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Guido eFerlazzo;Guido eFerlazzo;Barbara eMorandi
Journal sudebno-meditsinskaia ekspertiza
Year 2014
DOI
10.3389/fimmu.2014.00159
URL
http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00159/full
Keywords
humans dendritic cells natural killer cells allergy

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