the non-coding rna landscape of plasma cell dyscrasias

Clicks: 321
ID: 168631
2020
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Abstract
Despite substantial advancements have been done in the understanding of the pathogenesis of plasma cell (PC) disorders, these malignancies remain hard-to-treat. The discovery and subsequent characterization of non-coding transcripts, which include several members with diverse length and mode of action, has unraveled novel mechanisms of gene expression regulation often malfunctioning in cancer. Increasing evidence indicates that such non-coding molecules also feature in the pathobiology of PC dyscrasias, where they are endowed with strong therapeutic and/or prognostic potential. In this review, we aim to summarize the most relevant findings on the biological and clinical features of the non-coding RNA landscape of malignant PCs, with major focus on multiple myeloma. The most relevant classes of non-coding RNAs will be examined, along with the mechanisms accounting for their dysregulation and the recent strategies used for their targeting in PC dyscrasias. It is hoped these insights may lead to clinical applications of non-coding RNA molecules as biomarkers or therapeutic targets/agents in the near future.
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morelli2020cancersthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Eugenio Morelli;Annamaria Gullà;Roberta Rocca;Cinzia Federico;Lavinia Raimondi;Stefano Malvestiti;Valter Agosti;Marco Rossi;Giosuè Costa;Gianluca Giavaresi;Abdel Kareem Azab;Antonia Cagnetta;Michele Cea;Pierosandro Tagliaferri;Antonino Neri;Nikhil C. Munshi;Giuseppe Viglietto;Pierfrancesco Tassone;Nicola Amodio
Journal The Journal of investigative dermatology
Year 2020
DOI
10.3390/cancers12020320
URL
https://www.mdpi.com/2072-6694/12/2/320
Keywords
multiple myeloma non-coding rna mirna Oncology including cancer and carcinogens tumors

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