modeling myeloid malignancies using zebrafish

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ID: 168244
2017
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Abstract
Human myeloid malignancies represent a substantial disease burden to individuals, with significant morbidity and death. The genetic underpinnings of disease formation and progression remain incompletely understood. Large-scale human population studies have identified a high frequency of potential driver mutations in spliceosomal and epigenetic regulators that contribute to malignancies, such as myelodysplastic syndromes (MDS) and leukemias. The high conservation of cell types and genes between humans and model organisms permits the investigation of the underlying mechanisms of leukemic development and potential therapeutic testing in genetically pliable pre-clinical systems. Due to the many technical advantages, such as large-scale screening, lineage-tracing studies, tumor transplantation, and high-throughput drug screening approaches, zebrafish is emerging as a model system for myeloid malignancies. In this review, we discuss recent advances in MDS and leukemia using the zebrafish model.
Reference Key
potts2017frontiersmodeling Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Kathryn S. Potts;Kathryn S. Potts;Teresa V. Bowman;Teresa V. Bowman;Teresa V. Bowman
Journal international journal of heat and technology
Year 2017
DOI
10.3389/fonc.2017.00297
URL
http://journal.frontiersin.org/article/10.3389/fonc.2017.00297/full
Keywords
zebrafish hematopoiesis myelodysplastic syndrome acute myeloid leukemia splicing Oncology including cancer and carcinogens tumors

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