clinical research of perioperative serum vegf and mmp-9 levels in patients with non-small cell lung cancer
Clicks: 303
ID: 168203
2008
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Star Article
30.0
/100
303 views
42 readers
AI Quality Assessment
Not analyzed
Readership in this journal
StarRanked #25 of 101 articles by views in proceedings of the 10th acm multimedia systems conference, mmsys 2019
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Background and objective Angiogenesis is necessary in tumor progression and metastasis. Serumvascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) are important factors in angiogenesis.Elevated levels of VEGF and MMP-9 were reported in lung cancer. The aim of this research is to study the dynamic changes of serum VEGF and MMP-9 levels in non-small cell lung cancer (NSCLC) patients who underwent surgery. Methods Serum VEGF and MMP-9 levels were determined in 57 patients with NSCLC who were undergoing surgery byELISA (enzyme linked immunosorbent assay) method before operation and on postoperative day 1, 7, 14. At the same time18 patients with pulmonary benign diseases treated by surgery were studied as the control. Thirty healthy volunteers servedto define normal VEGF and MMP-9. Results Preoperative serum VEGF levels (685.50 pg/mL) was significantly higherin the group of patients with NSCLC compared with the benign and healthy group (respectively: 160.90 pg/mL, 94.40 pg/mL) (P <0.01); Serum VEGF levels were elevated after surgery and the levels were 1055.60 pg/mL, 1533.90 pg/mL, 1882.10 pg/mL, respectively, on postoperative day 1, 7, 14 (P <0.01). 2 Preoperative serum MMP-9 level (84.48 ng/mL) was significantly higher in the group of patients with NSCLC compared with the benign and healthy group (respectively:58.98 ng/mL and 42.94 ng/mL, P <0.01); Serum MMP-9 levels were elevated soon after surgery and the peak (282.99 ng/mL) was observed on postoperative day 1 in NSCLC. Then serum MMP-9 levels dropped (respectively: 221.14 ng/mL and 194.78 ng/mL on postoperative 7 and 14) (P <0.01). Conclusion Preoperative serum VEGF and MMP-9 levels were both significantly higher in the group of patients with NSCLC compared with the benign and healthy group. Perioperative serumVEGF and MMP-9 levels were both significantly elevated in patients with NSCLC.
| Reference Key |
hu2008chineseclinical
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Ying HU;Baolan LI;Changxing SONG |
| Journal | proceedings of the 10th acm multimedia systems conference, mmsys 2019 |
| Year | 2008 |
| DOI |
DOI not found
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.