dementia post-radiotherapy: improvement with acetylcholinesterase inhibitor a case report

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Abstract
Abstract Cognitive decline associated with radiotherapy is a progressive complication that affects many patients submitted to this form of treatment. The lack of an effective treatment drives research for new treatment options to improve the quality of life of patients with this disorder. We report the case of a 64 year-old man who developed a severe dementia of the frontal subcortical type, which was associated with subcortical frontal lesions and appeared as a late complication of radiotherapy used to treat a pituitary tumor. After many pharmacological attempts to improve his cognitive and behavioral problems, the patient showed a significant improvement in the cognitive, functional and behavioral impairments after treatment with an acetylcholinesterase inhibitor. This report discusses hypotheses for the positive effect of this treatment.
Reference Key
damindementiadementia Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Antonio Eduardo Damin;Lílian S. Morillo;Tíbor Rilho Perroco;Wilson Jacob Filho;Cássio Machado de Campos Bottino
Journal preventing school failure
Year Year not found
DOI
10.1590/S1980-57642009DN30100013
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642009000100068&lng=en&tlng=en
Keywords
dementia radiotherapy therapeutics cholinesterase inhibitors neurosciences neuropsychiatry biological psychiatry

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