mir-9-1 aberrant methylation is a frequent event in breast cancer and is associated with bone metastases
Clicks: 302
ID: 166870
2012
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Steady Performance
64.5
/100
302 views
220 readers
Trending
AI Quality Assessment
Not analyzed
Readership in this journal
SteadyRanked #8 of 43 articles by views in international journal of online engineering (ijoe)
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Abstract:
Background. Aberrant promoter methylation of classical tumor suppressor genes occurs frequently during carcinogenesis. Several lines of evidences suggest that this epigenetic change also regulates microRNAs expression and may represent a potential molecular marker for cancer.
Methods. We examined the methylation status at the hsa-miR-9-1 gene promoter in a series of 66 breast cancer cases by methylation sensitive PCR (MSP) analysis. For 43 of the 66 patients paired normal breast tissue and/or pre invasive (ADH, DCIS) lesions were also available. As control methylation status was determined on 6 normal breast tissues obtained from reductive mammoplasty.
Results. Methylation at mir-9-1 gene was detected in 32 out of 66 breast tumours (49%) and in none of the 6 normal breast tissues derived from reductive mammoplasty (P=0.02 χ2- Test). In all cases the same methylation status was demonstrated in tumour specimen, paired normal breast tissues and/or pre-invasive (ADH and DCIS) lesions. An higher frequency of methylation was found in patients showing metastases at diagnosis as compared with non metastatic patients (P=0.03 χ2-Test). Moreover, methylation at mir-9-1 gene was more frequent in patients showing bone metastases as first metastatic sites (P=0.04 χ2-Test), and in the subgroup of patients developing only bone metastases as compared with patients developing metastases to visceral organs (P=0.03 χ2-Test).
Conclusions. This study give further evidence of epigenetic mechanisms as regulators of miR-9 expression in breast cancer. Moreover, our results suggest an association between hypermethylation at the miR-9-1 gene and metastatic site.
| Reference Key |
florescu2012analelemir-9-1
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Anca Florescu |
| Journal | international journal of online engineering (ijoe) |
| Year | 2012 |
| DOI |
DOI not found
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.