long-term outcome after autologous stem cell transplantation with adequate peripheral blood stem cell mobilization using plerixafor and g-csf in poor mobilizer lymphoma and myeloma patients

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ID: 166869
2011
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Abstract
Poor peripheral blood stem cell (PBSC) mobilization predicts worse outcome for myeloma and lymphoma patients post autologous stem cell transplant (ASCT). We hypothesize that PBSC harvest using plerixafor and G-CSF in poor mobilizers may improve long-term outcome. We retrospectively analyzed the data on patients who had second PBSC mobilization using plerixafor and G-CSF as a rescue. Nine lymphoma and 8 multiple myeloma (MM) patients received the drug. A control group of 25 MM and lymphoma patients who were good mobilizers with G-CSF only was used for comparison. Sixteen of the 17 poor mobilizers proceeded to ASCT, and one MM patient had tandem transplants. Length of hospital stay, infection incidence, granulocyte engraftment, and long-term hematopoietic recovery were not significantly different between the two groups. In conclusion, all poor mobilizers were able to obtain adequate stem cells transplant dose and had similar transplant course and long-term outcome to that of the control good mobilizers group.
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moreb2011advanceslong-term Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Jan S. Moreb;Donya Salmasinia;Jack Hsu;Wei Hou;Christina Cline;Emma Rosenau
Journal the european journal of general practice
Year 2011
DOI
10.1155/2011/517561
URL
http://dx.doi.org/10.1155/2011/517561
Keywords
Diseases of the blood and blood-forming organs

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