orexin-a controls sympathetic activity and eating behavior

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ID: 166385
2014
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Abstract
It is extremely important for the health to understand the regulatory mechanisms of energy expenditure. These regulatory mechanisms play a central role in the pathogenesis of body weight alteration. The hypothalamus integrates nutritional information derived from all peripheral organs. This region of the brain controls hormonal secretions and neural pathways of the brainstem. Orexin-A is a hypothalamic neuropeptide involved in the regulation of feeding behavior, sleep-wakefulness rhythm, and neuroendocrine homeostasis. This neuropeptide is involved in the control of the sympathetic activation, blood pressure, metabolic status, and blood glucose level. This minireview focuses on relationship between the sympathetic nervous system and orexin-A in the control of eating behavior and energy expenditure. The thermoregulatory hypothesis of food intake is analyzed, underlining the role played by orexin-A in the control of food intake related to body temperature. Furthermore, the paradoxical eating behavior induced orexin-A is illustrated in this minireview.
Reference Key
emessina2014frontiersorexin-a Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Giovanni eMessina;Carmine eDalia;Domenico eTafuri;Vincenzo eMonda;Filomena ePalmieri;Amelia eDato;Angelo eRusso;Saverio eDe Blasio;Antonietta eMessina;Vincenzo eDe Luca;Sergio eChieffi;Marcellino eMonda
Journal accounts of chemical research
Year 2014
DOI
10.3389/fpsyg.2014.00997
URL
http://journal.frontiersin.org/Journal/10.3389/fpsyg.2014.00997/full
Keywords
body weight energy expenditure sympathetic nervous system eating behaviourpsychology

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