study of t-cell subsets, b and nk cells in iranian patients with behcet's disease by monoclonal antibodies

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ID: 166334
1995
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Abstract
Behcet disease (BD) is a systemic inflammatory disease of the unknown etiology. There is however, some evidence to suggest that immunological abnormalities are important in its pathogenesis, furthermore several T-cell abnormalities which may be quite relevant to autoimmune origin of the disease have been described. We report here our study of T-cell subsets, B and NK cells in 68 patients with BD in comparison to 30 normal controls, by monoclonal antibodies against CD3 (pan T-cell), CD4 (Helper) CD8 (Suppressor/cytotoxic), CD22 (B-cell) and CD16 (NK-cell) markers. The results show the increase (P=0.008) of T (CD3), T (CD4) (P<0.000001) and decrease of T (CD8) (P<0.000001) and reduction in ratio of CD4/CD8 cells (P<0.000001), but any alteration in B and NK cells number were not seen. In patients with BD 69.8% negative PPD test and above results suggests that the cellular immunity in these patients is anergic, which may be an important etiological factor.
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m1995tehranstudy Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Rayyani M;Masoud A;Davachi F
Journal asian journal of chemistry
Year 1995
DOI
DOI not found
URL
http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/5938.pdf&manuscript_id=5938
Keywords
Medicine (General)

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