relationship of nogo-a gene expression in serum and cerebrospinal fluid with nerve injury and inflammatory factor levels in patients with craniocerebral trauma
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ID: 166052
2017
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Abstract
Objective: To study the relationship of Nogo-A gene expression in serum and cerebrospinal
fluid with nerve injury and inflammatory factor levels in patients with craniocerebral trauma.
Methods: 82 patients with craniocerebral trauma who were treated in our hospital between
January 2015 and February 2017 were collected as observation group, and 58 normal subjects
who received internal hemorrhoids surgery under lumbar anesthesia in our hospital during
the same period were collected as control group. Fluorescence quantitative PCR method was
used to detect Nogo-A gene expression in serum and cerebrospinal fluid of both groups, and
enzyme-linked immunosorbent assay (ELISA) was used to determine serum levels of nerve
injury indexes and inflammatory factors in two groups. Pearson test was used to assess the
relationship of Nogo-A gene expression in serum and cerebrospinal fluid with disease severity
in patients with craniocerebral trauma. Results: Nogo-A mRNA expression in the serum and
cerebrospinal fluid of observation group were higher than those of the control group; serum
IGF-Ⅱ level was lower than that of control group while NSE, MBP and S100B levels were
higher than those of control group; serum HSP-70, PCT, IL-1β, IL-6 and CRP levels were
higher than those of control group. Pearson test showed that Nogo-A gene expression in serum
and cerebrospinal fluid of patients with craniocerebral trauma were directly correlated with
the nerve injury degree and inflammatory factor levels. Conclusions: Nogo-A gene is highly
expressed in patients with craniocerebral trauma, and its expression is directly correlated with
the nerve injury and systemic inflammatory response.
| Reference Key |
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| Authors | ;Tao Chang1;Li Wang2;Xiao-Ping Zhao1;Hua Lyu2 |
| Journal | journal of communications |
| Year | 2017 |
| DOI |
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