genome-wide association study identifies loci at atf7ip and klk2 associated with percentage of circulating free psa
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ID: 165729
2013
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Abstract
BACKGROUND: Percentage of free-to-total prostate-specific antigen (%fPSA) is an independent predictor of risk for prostate cancer among men with modestly elevated level of total PSA (tPSA) in blood. Physiological and pathological factors have been shown to influence the %fPSA value and diagnostic accuracy.
MATERIALS/METHODS: To evaluate genetic determinants of %fPSA, we conducted a genome-wide association study of serum %fPSA by genotyping 642,584 single nucleotide polymorphisms (SNPs) in 3192 men of European ancestry, each with a tPSA level of 2.5 to 10 ng/ml, that were recruited in the REduction by DUtasteride of Prostate Cancer Events study. Single nucleotide polymorphisms (SNPs) with P <10−5 were further evaluated among the controls of a population-based case-control study in Sweden (2899 prostate cancer cases and 1722 male controls), including 464 controls having tPSA levels of 2.5 to 10 ng/ml.
RESULTS: We identified two loci that were associated with %fPSA at a genome-wide significance level (P <5 ×10−8). The first associated SNP was rs3213764 (P = 6.45 × 10−10), a nonsynonymous variant (K530R) in the ATF7IP gene at 12p13. This variant was also nominally associated with tPSA (P = .015). The second locus was
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jin2013neoplasia:genome-wide
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| Authors | ;Guangfu Jin;Siqun Lilly Zheng;Hans Lilja;Seong-Tae Kim;Sha Tao;Zhengrong Gao;Tracey Young;Fredrik Wiklund;Junjie Feng;William B. Isaacs;Roger S. Rittmaster;Henrik Gronberg;Lynn D. Condreay;Jielin Sun;Jianfeng Xu |
| Journal | ACS chemical neuroscience |
| Year | 2013 |
| DOI |
10.1593/neo.121620
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| URL | |
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