effects of nucleos(t)ide analogues on estimated glomerular filtration rate and serum creatinine level in patients with chronic hepatitis b

Clicks: 404
ID: 165410
2016
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #3 of 78 articles by views in lontar komputer

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
ObjectiveTo investigate the effects of nucleos(t)ide analogues (NAs) on the estimated glomerular filtration rate (eGFR) and serum creatinine (Scr) in patients with chronic hepatitis B (CHB). MethodsA total of 184 patients with CHB who visited and were hospitalized in the Second Affiliated Hospital of Dalian Medical University from September 2010 to September 2014 were enrolled and divided into adefovir (ADV) group (58 patients), telbivudine (LDT) group (62 patients), and entecavir (ETV) group (64 patients), according to the NAs administered. The course of treatment was 104 weeks for all groups. The changes in eGFR and Scr level in each group after treatment were evaluated. The chi-square test was applied for comparison of categorical data between groups; the Wilcoxon rank sum test was applied for comparison of continuous data before and after treatment within one group, and Kruskal-Wallis H rank sum test was applied for comparison between groups. ResultsIn the ETV group, there were no significant changes in Scr and eGFR after 52 and 104 weeks of treatment (all P＞0.05); in the ADV group, there was a significant increase in Scr level and a significant reduction in eGFR after 52 and 104 weeks of treatment (Z=-3.020, -3.456, -4.623, and -4.831, P=0.018, 0.008, 0.004, and ＜0001, respectively); in the LDT group, there was a significant reduction in Scr level and a significant increase in eGFR after 52 and 104 weeks of treatment (Z=-5596, -5.687, -5.335, and -5.162, P=0.007, 0.003, 0.002, and ＜0.001, respectively). After 104 weeks of treatment, the distribution of eGFR showed a significant difference between the ADV group and the LDT group (χ2=21.039, P＜0.001); in the LDT group, 77.78% (7/9) of all the patients achieved eGFR ≥90 ml·min-1·1.73 m-2, and in the ADV group, 23.81%(10/42) of all the patients achieved eGFR ＜90 ml·min-1·1.73 m-2. ConclusionDuring the treatment, LDT can increase eGFR and improve renal function significantly,while ADV may reduce eGFR, with potential nephrotoxicity. During the treatment for patients with CHB, eGFR may reflect renal injury much earlier than Scr. The mechanisms of action of LDT in increasing eGFR and protecting renal function await further investigation.
Reference Key
yong2016linchuangeffects Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;XU Yong;Feng Jihong
Journal lontar komputer
Year 2016
DOI
10.3969/j.issn.1001-5256.2016.02.016
URL
http://www.lcgdbzz.org/qk_content.asp?id=7144
Keywords
nucleotides hepatitis b chronic nucleosides Gastroenterology glomerular filtration ratediseases of the digestive system

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.