in vitro glucuronidation of ochratoxin a by rat liver microsomes

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ID: 165381
2013
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Abstract
Ochratoxin A (OTA), one of the most toxic mycotoxins, can contaminate a wide range of food and feedstuff. To date, the data on its conjugates via glucuronidation request clarification and consolidation. In the present study, the combined approaches of ultra high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS), UHPLC-Orbitrap-high resolution mass spectrometry (HRMS) and liquid chromatography-multiple stage mass spectrometry (LC-MSn) were utilized to investigate the metabolic profile of OTA in rat liver microsomes. Three conjugated products of OTA corresponding to amino-, phenol- and acyl-glucuronides were identified, and the related structures were confirmed by hydrolysis with β-glucuronidase. Moreover, OTA methyl ester, OTα and OTα-glucuronide were also found in the reaction solution. Based on these results, an in vitro metabolic pathway of OTA has been proposed for the first time.
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han2013toxinsin Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Zheng Han;Emmanuel K. Tangni;José Diana Di Mavungu;Lynn Vanhaecke;Sarah De Saeger;Aibo Wu;Alfons Callebaut
Journal matec web of conferences
Year 2013
DOI
10.3390/toxins5122671
URL
http://www.mdpi.com/2072-6651/5/12/2671
Keywords
metabolic pathway ochratoxin a glucuronidation

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